Triple threat

The triple threat of aspiration pneumonia.

A spiration pneumonia is a disease recognized since antiquity, yet there are few conditions in pulmonary medicine as frequent in occurrence but as lacking in consensus regarding classification and treatment. The priority for clinical description belongs to Hippocrates,’ the first scientific investigalion is ascribed to John Hunters in 1781, and the “classic study” is credited to Mendelson in 19...

Triple threat: adiposity, aging, atrial fibrillation

FMRP: a triple threat to PSD-95

Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al., 2008). There is a strong genetic basis for autism, which is highly comorbid with singlegene disorders including fragile X syndrome (FXS) (Wang et al., 2010). The main challenges that have plagued the field incl...

Heme oxygenase-1: a multifaceted triple-threat molecule.

Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the antioxidant, anti...

Microbiology. Triple-threat microbe gained powers from another bug.

The long-dreaded superbug surfaced on a summer Friday in 2002. The new strain of Staphylococcus aureus, cultured from foot ulcers on a diabetes patient in a Detroit dialysis center, had developed resistance to vancomycin, one of the few antibiotics left that reliably kills staph. Doctors rushed the strain to the Centers for Disease Control and Prevention in Atlanta, and nine local and CDC publi...